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首页> 外文OA文献 >Effect Of Extracts From Araticum (annona Crassiflora) On Ccl4-induced Liver Damage In Rats [influência Dos Extratos Etanólicos De Araticum (annona Crassiflora) Na Atividade Das Enzimas Hepáticas De Ratos Intoxicados Por Ccl4]
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Effect Of Extracts From Araticum (annona Crassiflora) On Ccl4-induced Liver Damage In Rats [influência Dos Extratos Etanólicos De Araticum (annona Crassiflora) Na Atividade Das Enzimas Hepáticas De Ratos Intoxicados Por Ccl4]

机译：菊芋提取物对Ccl4诱导的大鼠肝损伤的影响

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The influence of ethanolic extracts of Annona crassiflora on the activities of hepatic antioxidant enzymes was examined. Extracts of A. crassiflora seeds and peel were administered orally (50 mg of galic acid equivalents.kg-1) to Wistar rats for 14 consecutive days followed by a single oral dose of carbon tetrachloride (CCl4, 2 g.kg-1). Lipid peroxidation and the activities of hepatic catalase (CAT), cytochromes P450 (CP450) and b5, glutathione peroxidase (GPx), glutathione reductase (GRed), superoxide dismutase (SOD), and the content of glutathione equivalents (GSH) were evaluated. The treatment with CCl4 increased lipid peroxidation, the level of GSH equivalents and the content of cytochrome b5 by 44, 140 and 32%, respectively, with concomitant reductions of 23, 34 and 39% in the activities of CAT, SOD, and CP450, respectively. The treatment with A. crassiflora seeds and peel extracts alone inhibited lipid peroxidation by 27 and 22%, respectively without affecting the CP450 content. The pretreatment with the A. crassiflora extracts prevented the lipid peroxidation, the increase in GSH equivalents and the decrease in CAT activity caused by CCl4, but it had no effect on the CCl4-mediated changes in CP450 and b5 and SOD. These results show that A. crassiflora seeds and peel contain antioxidant activity in vivo that could be of potential therapeutic use.
机译：研究了番荔枝番荔枝的乙醇提取物对肝脏抗氧化酶活性的影响。连续14天对Wistar大鼠口服给予A. crassiflora种子和果皮提取物（50 mg的加仑酸当量。kg-1），然后口服一次四氯化碳（CCl4，2 g.kg-1）。评估脂质过氧化和肝过氧化氢酶（CAT），细胞色素P450（CP450）和b5，谷胱甘肽过氧化物酶（GPx），谷胱甘肽还原酶（GRed），超氧化物歧化酶（SOD）的活性以及谷胱甘肽当量（GSH）的活性。 CCl4处理可使脂质过氧化作用，GSH当量水平和细胞色素b5含量分别增加44％，140％和32％，同时CAT，SOD和CP450的活性分别降低23％，34％和39％，分别。单独用景天种子和果皮提取物处理可分别将脂质过氧化抑制27％和22％，而不会影响CP450含量。景天提取物的预处理可以防止脂质过氧化，GSH当量的增加和CCl4引起的CAT活性的降低，但对CCl4介导的CP450和b5和SOD的变化没有影响。这些结果表明，景天种子和果皮在体内具有抗氧化活性，可能具有潜在的治疗用途。

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    Roesler R.;

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  • 年度 2015
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